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Psoriatic Arthritis Pocket Guide
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Psoriatic Arthritis Pocket Guide
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New And Emerging Treatments Español

The mechanism of apremilast includes all of the following EXCEPT:

Inhibition of PDE4

Increase cAMP levels

Upregulation of NFkB signaling

Deactivation of Protein Kinase A

A 35 yo male presents with active psoriatic arthritis. Radiographs of his hands show joint erosions and joint space narrowing. The patient request a medication that will slow or arrest his joint damage. Based on clinical trial data, which of the following medications would you recommend?

Adalimumab

Apremilast

Methotrexate

Leflunomide

Which of the statements regarding IL-23 is TRUE?

IL-23 is released by plasmacytoid dendritic cells

IL-23 shares the subunit p19 with IL-12

IL-23 binding to its receptor on naïve T cells can induce a pathologic T cell subset

IL-23 directly promotes keratinocyte proliferation in psoriatic plaques

A 38 yo male on adalimumab for severe erosive psoriatic arthritis and previously severe psoriasis, now in remission, develops focal neurologic deficits and MRI shows cortical lesions in the white matter. A workup for multiple sclerosis is negative. The adalimumab is discontinued and steroids at a dose of 1 mg/kg are started with resolution of the neurologic symptoms and marked improvement on MRI of the cortical lesions. The steroids are tapered and his skin and joints flare. What is the most reasonable therapeutic intervention based on the literature?

Restart adalimumab and watch closely for new neurologic symptoms

Start another anti-TNF agent

Start ustekinumab

Continue prednisone at 20 mg per day and add leflunomide

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The mechanism of apremilast includes all of the following EXCEPT:

of your peers answered this correctly on the pre-test
of your peers answered this correctly on the post-test

Inhibition of PDE4

Increase cAMP levels

Upregulation of NFkB signaling

Deactivation of Protein Kinase A

A 35 yo male presents with active psoriatic arthritis. Radiographs of his hands show joint erosions and joint space narrowing. The patient request a medication that will slow or arrest his joint damage. Based on clinical trial data, which of the following medications would you recommend?

of your peers answered this correctly on the pre-test
of your peers answered this correctly on the post-test

Adalimumab

Apremilast

Methotrexate

Leflunomide

Which of the statements regarding IL-23 is TRUE?

of your peers answered this correctly on the pre-test
of your peers answered this correctly on the post-test

IL-23 is released by plasmacytoid dendritic cells

IL-23 shares the subunit p19 with IL-12

IL-23 binding to its receptor on naïve T cells can induce a pathologic T cell subset

IL-23 directly promotes keratinocyte proliferation in psoriatic plaques

A 38 yo male on adalimumab for severe erosive psoriatic arthritis and previously severe psoriasis, now in remission, develops focal neurologic deficits and MRI shows cortical lesions in the white matter. A workup for multiple sclerosis is negative. The adalimumab is discontinued and steroids at a dose of 1 mg/kg are started with resolution of the neurologic symptoms and marked improvement on MRI of the cortical lesions. The steroids are tapered and his skin and joints flare. What is the most reasonable therapeutic intervention based on the literature?

of your peers answered this correctly on the pre-test
of your peers answered this correctly on the post-test

Restart adalimumab and watch closely for new neurologic symptoms

Start another anti-TNF agent

Start ustekinumab

Continue prednisone at 20 mg per day and add leflunomide

Results

Your score on the post-test improved over the pre-test.

Pre-Test
Module Content
Post-Test

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